Identifying the genetic determinants of transcription factor activity
نویسندگان
چکیده
منابع مشابه
Identifying the genetic determinants of transcription factor activity
Analysis of parallel genotyping and expression profiling data has shown that mRNA expression levels are highly heritable. Currently, only a tiny fraction of this genetic variance can be mechanistically accounted for. The influence of trans-acting polymorphisms on gene expression traits is often mediated by transcription factors (TFs). We present a method that exploits prior knowledge about the ...
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ژورنال
عنوان ژورنال: Molecular Systems Biology
سال: 2010
ISSN: 1744-4292,1744-4292
DOI: 10.1038/msb.2010.64